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Heparin, Buy Heparin Online
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|  | | Heparin - 5 Vials x 5 ml (5000 IU)Package: 5 Vials x 5 ml (5000 IU)
Usage: Injectable
It is used to stop blood clots forming within the blood vessels
| | | | Price: $79.00 | | | |
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Heparin, Buy Heparin Online
Brand names: Hep-Pak, Heparin Lock Flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage.
Generic Name: heparin (HEP a rin).
Heparin is a member of the drug classes known as anticoagulants. A question appears: what is the function of an anticoagulant? The function of anticoagulants is to prevent coagulation; it means that anticoagulant stops blood from clotting. But it can't decrease the volume of the blood clots which have been already developed. It is essentially to notice that this medication has other functions too. The most important goal of this product is to fight against invading bacteria and other foreign materials.
This preparation is administrated by injection into a vein or under the skin (subcutaneously). It must not be injected into a muscle.
Structure of Heparin
Heparin consists of a differently sulfated repeating disaccharide unit. The most general disaccharide unit is composed of a 2-O-sulfatediduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S). For example, it makes up 85% of heparins from beef lung and about 75% of those from porcine intestinal mucosa.
The major sugars that occur in this product are listed below:
α-L-iduronic acid 2-sulfate;
2-deoxy-2¬sulfamino-α-D-glucose 6-sulfate;
β-D-glucuronic acid;
2-acetamido-2-deoxy-α-D¬glucose;
α-L-iduronic acid.
The sugars enumerated above are present in decreasing amounts, as a regular in the order (2) > (1) > (4) > (3) > (5). This drug is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups.
Mechanism of action of heparin
It has been already noticed that this preparation stops blood from clotting. How does it act? It inactivates thrombin. In order to neutralize thrombin this product links itself to the coagulation enzyme and antithrobin. The activated antithrombin inactivates thrombin and other proteases caused blood clotting. So, wee understand that antithrombin suppresses coagulation by inactivating proteins that are involved in the coagulation cascade.
Administration of Heparin
Heparin is administrated in case of dialysis, during extracorporeal circulation ardiopulmonary bypass for heart surgery.
Heparin is taken to cure patients with following illnesses:
peripheral occlusive disease;
thromboprophylaxis;
acute coronary syndrome;
atrial fibrillation;
deep-vein thrombosis and pulmonary embolism.
Heparin dosage
The recommended dosage of heparin depends upon some conditions. The dose is based on the coagulation test results. These tests should be performed enough often. The determination of coagulation time henges on specific conditions. If this product is used by continous intravenous infusion, the coagulation tests must be performed approximately each four hours in the early stages of treatment. When the preparation is administered periodically by intravenous injection, coagulation tests should be performed before each injection during the early stages of treatment.
In case of deep vein Thrombosis – Prophylaxis usual the prescribed dose is 5000 units subcutaneously each 8 to 12 hours.
Usual dose for anticoagulation in case of pregnancy is 5000 units under the skin each 12 hours.
Usual adult dose for thrombotic disorder is100 units/mL every 6 to 8 hours for PVC catheters and peripheral heparin locks. But when stagnant blood is observed in catheter after it was utilized for drug or blood administration, it is necessary to add flushes. The dose for babies that suffer of thrombotic disorder is 10 units each 6 to 8 hours. Child dosage in case mentioned above is 100 units/mL every 6 to 8 hours. Additional flushes must be given when stagnant blood is noticed in catheter, after catheter is used for medication or blood administration.
If a person has got a massive pulmonary embolism, the initial dosage may be an IV bolus of 10,000 units which are followed by 1500 units per hour.
Possible adverse effects of heparin
Heparin, as any medication may lead to unwanted effects. A lot of people using this preparation do not have got serious negative reactions. Some general unwanted reactions of this medication are following: swelling at injection site, bone ache, easily broken bones. Pain and loss of feeling in the arms and legs, change in color of the arms and legs, chest pain, difficult breathing, confusion, weakness on one side of the body, slurred speech, vision changes.
Heparin can lead to some other negative results: signs of serious bleeding, including unusual pain, swelling, discomfort, long-term bleeding from cuts, continous nosebleeds, unusually heavy and long-term menstrual periods, unusual easy bruising, dark urine, black stools, severe headache, unusual dizziness.
Serious allergic symptoms were reported rarely, but sometimes they can occur. If you utilize this drug and notice such consequences as rash, itching, swelling, severe dizziness, difficult breathing and others, call your doctor.
There are such adverse symptoms that are caused in case of long-term Heparin using; others can be results of a systematic using of this drug. For example, osteoporosis can be caused by long-term utilizing of high dosages of this medicine, cutaneous necrosis has been reported after systemic utilizing; inhibition of aldosterone synthesis, delayed transient alopecia, priapism, and rebound hyperlipemia on ceasing of this drug have also been reported.
Significant elevations of aminotransferase grades have occurred in a high percentage of patients and healthy persons who have received this preparation.
Coumadin and Heparin
Coumadin and Heparin are anticoagulants, so they both stop blood from clotting. They are used to treat such conditions as embolism and thrombosis. Even though they sound similar, coumadin and heparin have got a lot of differences. As for adninstrating them, coumadin is used orally, heparin is usedin a form of injection. Coumadin must not be used by pregnant women, heparin may be administrated by pregnant women. Coumadin and heparin may lead to excessive bleeding which may be life-threatening.
Heparin recall
Firstly, let metion what medication recalls are. Drug recalls are such acts that are taken in order to remove some medications from the market.
As for Heparin, the most of recalls were in 2008 as a result of negative results of heparin which was manufactured in China.
But there were no any recalls related to heparin which was manufactured by B. Braun Medical Inc. B.Braun manufacturer advices to discontinue heparin use and contact your doctor, if any side reactions are noticed.
Heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is a form of thrombocytopenia which was developed as a result of administration of heparin. Thus, it is a side effect that was produced by heparin use. There are two types of Hit: type 1 and type 2. HIT type 2 is a more severe negative consequence than HIT type 2. HIT type 2 may be a fatal aspect. In order to claim that a patient has HIT, he must perform certain laboratory tests.
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